合生元首席科学家Patrice博士告献策 让宝宝远离便秘

　　Right!

　　是的!

　　小记：

　　Then, what technologies are Biostime using in the infant formula to decrease baby’s constipation?

　　那么，合生元配方奶粉是通过什么新方法降低宝宝喝后的便秘发生率?

　　P：

　　Biostime has made the choice to replace the classical vegetable oils that is used in all infant formula in China by B-Vegetable oils which structure is closer to the human breast milk lipids. Especially the palmitic acid is in majority at the B position of the triglyceride molecule and allows a better lipid and calcium absorption and no calcium soap formation. These formula are very effective to alleviate constipation in babies as proved by several large scale clinical studies.

　　合生元决定用结构与母乳脂肪一致的β-植物油，来取代中国市场上其它婴儿配方奶粉所用的普通植物油。在β-植物油中，软脂酸主要位于甘油骨架的β-位上，使得脂肪和钙更容易被消化吸收，不会形成钙皂。多个大规模临床试验已经证实，包含β-植物油的婴儿配方奶粉能够有效减少婴儿便秘的产生。

　　小记：

　　You just mentioned that β-Vegetable oil can prevent baby’s constipation; please tell us more about the theories. Do we have any data supporting?

　　您刚刚有说到β—植物油可以预防便秘，您能为我们解释下原因吗?请问有这方面的数据支持吗?

　　P：

　　To penetrate into the enterocytes which are the intestinal cell lines absorbing nutrients in the intestine, the lipids have to be hydrolyzed by an enzyme name pancreatic lipase. This enzyme preferentially hydrolyses the alpha and gamma bounds of the triglyceride molecule leaving one fatty acid in the B-bound. If the fatty acid “palmitic acid” is on alpha and gamma position it will be released as free fatty acid in the intestine and will bound to calcium to form the insoluble calcium soap. In our B-Vegetable oil, the palmitic acid is on Beta position and will not be hydrolyzed. Instead it will enter into the enterocytes with the remaining glycerol molecule. As a result we will have a better lipid absorption, a better calcium absorption (important for bone strength) and no calcium soap formation which again is responsible for constipation.深入到负责吸收营养的小肠上皮细胞，我们就会发现，脂肪必须经过胰脂肪酶分解后才能吸收。胰脂肪酶有选择地分解甘油三酯的α-和γ-位，同时保留β-位脂肪在甘油骨架上。如果软脂酸是在α和γ位的话，它在小肠中就会以游离脂肪酸的形式分解出来，然后会与钙结合形成不溶性钙皂。在我们的β-植物油中，软脂酸是在β位上，因而不会分解出来。相反的是，它们会保留在甘油骨架上并被小肠上皮细胞所吸收。结果就是，脂肪吸收更好，钙吸收也很好(这对于骨骼非常重要)，没有钙皂形成，也就没有了便秘。